Micromechanics of the Meiotic / Mitotic Spindle
نویسندگان
چکیده
منابع مشابه
Katanin controls mitotic and meiotic spindle length
Accurate control of spindle length is a conserved feature of eukaryotic cell division. Lengthening of mitotic spindles contributes to chromosome segregation and cytokinesis during mitosis in animals and fungi. In contrast, spindle shortening may contribute to conservation of egg cytoplasm during female meiosis. Katanin is a microtubule-severing enzyme that is concentrated at mitotic and meiotic...
متن کاملThe mitotic spindle checkpoint
One of the most awe-inspiring demonstrations in biology is a timelapse video of mitosis viewed with high magnification phase contrast or Nomarski DIC microscopy. From initial chaotic movement comes the orderly alignment of chromosomes at the metaphase plate followed by a flawlessly synchronous splitting of the chromosomes and their gliding separation to the two mitotic poles. Enforcing the timi...
متن کاملThe Influence of Meiotic Spindle Configuration by Cysteamine during in vitro Maturation of Mouse Oocytes
Background: The aim of this study was to assess effects of cysteamine as an anti-oxidant on rate of in vitro maturation of oocyte and determination of its effects on spindle size and shape. Methods: Pre-mature mice were primed with pregnant mare stimulating gonadotrophin (PMSG) and germinal vesicle (GV) stage oocytes were obtained 48 h after. The oocytes were cultured in tissue culture medium (...
متن کاملMos overexpression in Swiss 3T3 cells induces meiotic-like alterations of the mitotic spindle.
High levels of mos protooncogene product are expressed during oocyte meiotic maturation and Mos has been implicated in formation of the spindle and spindle pole. Here, we show that in Swiss 3T3 cells with 4N DNA content, high levels of Mos lead to the production of binucleated cells. The Swiss 3T3 cells in mitosis, before binucleation occurs, are anastral and the spindle poles are juxtaposed to...
متن کاملAcrylamide effects on kinesin-related proteins of the mitotic/meiotic spindle.
The microtubule (MT) motor protein kinesin is a vital component of cells and organs expressing acrylamide (ACR) toxicity. As a mechanism of its potential carcinogenicity, we determined whether kinesins involved in cell division are inhibited by ACR similar to neuronal kinesin [Sickles, D.W., Brady, S.T., Testino, A.R., Friedman, M.A., and Wrenn, R.A. (1996). Direct effect of the neurotoxicant a...
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ژورنال
عنوان ژورنال: Seibutsu Butsuri
سال: 2009
ISSN: 0582-4052,1347-4219
DOI: 10.2142/biophys.49.250